The Lyme Disease - Direct and Indirect Panel panel contains 2 tests with 16 biomarkers. Lyme Disease - Direct and Indirect PanelBoth indirect (Serology) and direct tests (PCR) should be routinely used for the accurate, sensitive, and specific laboratory detection of Lyme disease. Because of the complex nature of the disease, no single test is adequate for all clinical situations. Lyme Disease (Borrelia spp) DNA, Qualitative, Real-Time PCR, Blood Lyme Disease Antibodies (IgG, IgM), Immunoblot Clinical Significance. The diagnosis of Lyme disease is most often made by clinical examination combi