Thiopurine Methyltransferase (TPMT), Enzyme Activity

Description
The TPMT Activity test contains 1 test with 1 biomarker. Help prevent hepatotoxicity from thiopurine therapy. This test helps identify individuals at increased risk of hepatotoxicity from thiopurine dose escalation. Patients with a TMPT activity of 4-12 nmol 6-MMP/hr/mL RBC (heterozygote/low metabolizer) are at increased risk and may require a lower dose of thiopurine drug.
Disease/Condition
Autoimmune, Drug Monitoring, Inflammatory Bowel Disease (IBD), Rheumatoid Arthritis (RA)
Location
This test requires in-person visit to provider's patient service station near your location
In-person visit
Specimen
 Venous blood will be collected from your vein by healthcare professional
Blood (Venous)
Type
Chromatography/Mass Spectrometry
Analytes Included
  • Thiopurine Methyltransferase (TPMT)
More Info
Patients with a TMPT activity of 4-12 nmol 6-MMP/hr/mL RBC (heterozygote/low metabolizer) are at increased risk and may require a lower dose of thiopurine drug.