Description
The TPMT Activity test contains 1 test with 1 biomarker. Help prevent hepatotoxicity from thiopurine therapy. This test helps identify individuals at increased risk of hepatotoxicity from thiopurine dose escalation. Patients with a TMPT activity of 4-12 nmol 6-MMP/hr/mL RBC (heterozygote/low metabolizer) are at increased risk and may require a lower dose of thiopurine drug.
Disease/Condition
Autoimmune,
Drug Monitoring,
Inflammatory Bowel Disease (IBD),
Rheumatoid Arthritis (RA)
Location
Specimen
Type
Chromatography/Mass Spectrometry
Analytes Included
- Thiopurine Methyltransferase (TPMT)
More Info
Patients with a TMPT activity of 4-12 nmol 6-MMP/hr/mL RBC (heterozygote/low metabolizer) are at increased risk and may require a lower dose of thiopurine drug.